Pueraria Mirifica
Scientific Name(s) : Pueraria Mirifica
Family : Leguminosae
Common Name(s) : Kwao Krua Kao, White Kwao Krua (Thailand)
Chemical Composition
The compounds that make Pueraria mirifica different from any other phytoestrogen-containing plants in the
Family Leguminosae are Miroestrol and Deoxymiroestrol, which possess highest estrogenic activity among
the known phytoestrogens due to structural similarity to estradiol. Miroestrol was actually the first
compound isolated from this plant by a group of German chemists in 1940, but the plant had been
mistakenly reported then as Butea superba. It was later on classified as a new plant called Pueraria mirifica
Airy Shaw et Suvatabhandu.
The isolation and identification of deoxymiroestrol from the root of Pueraria mirifica has just been reported
in the February 2000 issue of the Journal of Natural Products. The authors proposed that since
deoxymiroestrol is easily oxidized to miroestrol, deoxymiroestrol, not the previously reported Miroestrol, is
more to be the actual chemical constituent of Pueraria mirifica. However, it is very likely that the two
phytoestrogens coexist in the root of t his plant. As shown below, the chemical structures of the two
compounds are very similar to that of estradiol, the main human estrogen.
In addition to miroestrol and deoxymiroestrol, Pueraria mirifica also contains other chemicals that belong to
isoflavone and coumestran groups of phytoestrogens, e.g., Genistein, Daidzein, Daidzin, Genistin, and
Coumestrol that are usually found in soybeans. However, the estrogenic activity of Miroestrol and
Deoxymiroestrol is much more potent than that of soy isoflavones.
Pharmaceutical Grade
Pueraria Mirifica
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