Pueraria Mirifica
Scientific Name(s) : Pueraria Mirifica
Family : Leguminosae
Common Name(s) : Kwao Krua Kao, White Kwao Krua (Thailand)
Toxicity Study
Toxicity study of Pueraria mirifica has recently been conducted in male and female Wistar rats by the
Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health and by the
Department of Biology, Faculty of Science, Chulalongkorn University. The animals were given the
suspension of root powder in water orally at the dose range between 10-1000 milligrams per kilogram of
body weight per day continuously for a period of ninety days.
From the animal toxicity study, no estrogenic effect was observed at the doses of 10 mg/kg/day. The
histopathological studies and biochemical data at different dose levels in rats of both sexes suggested that
the maximum tolerated dose in rats would be around 100 mg/kg/day. When consider the uncertainty factor
for the difference in the species and sensitivity among individuals, it is concluded that the safe dosage of
Pueraria mirifica as a dietary supplement for human should be about 1-2 mg/kg/day or about 50-100
mg/day.
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